SidaGhanaV1, Main, Exploration, bibRecord, 001317

Bacteriuria in a cohort of predominantly HIV-1 seropositive female commercial sex workers in Nairobi, Kenya

Identifieur interne : 001317 ( Main/Exploration ); précédent : 001316; suivant : 001318

Bacteriuria in a cohort of predominantly HIV-1 seropositive female commercial sex workers in Nairobi, Kenya

Auteurs : J. Ojoo [Kenya] ; J. Paul [Royaume-Uni] ; B. Batchelor [Royaume-Uni] ; M. Amir [Kenya] ; J. Kimari [Kenya] ; C. Mwachari [Kenya] ; J. Bwayo [Kenya] ; F. Plummer [Kenya] ; G. Gachihi [Kenya] ; P. Waiyaki [Kenya] ; C. Gilks [Kenya, Royaume-Uni]

Source :

Journal of Infection [ 0163-4453 ] ; 1996.

RBID : ISTEX:290FA3DB06CDF3914ED0E57BD2DFECB144815DF8

English descriptors

Abstract

Although significant bacteriuria and urinary tract infection are more common in immunocompetent women than men, studies linking HIV immunosuppression with an increased risk of developing urinary infection have so far only been carried out in men. We therefore examined the relationship between bacteriuria and HIV status and CD4+cell count in a relatively homogenous cohort of female commercial sex workers (CSW) attending a community clinic in Nairobi. Two hundred and twenty-two women were enroled, and grouped according to HIV status and CD4 count. Group 1 were HIV seronegative (n = 52); Group 2 were HIV seropositive with CD4 + counts above 500 × 106/1 (n = 51); Group 3 were HIV seropositive with CD4 + counts between 201 and 500 × 106/1 (n = 67); Group 4 were HIV seropositive with CD4 + counts below 200 × 106/1 (n = 52). Clinical signs and symptoms were noted and mid-stream specimens of urine obtained for culture and sensitivity.Overall 23% (50/222) had significant bacteriuria. The rates in each group respectively were 25%, 29%, 19% and 23% and there was no significant association between bacteriuria and HIV status; or between bacteriuria and level of immunosuppression as indicated by CD4 + count. Overall 19% (30/222) of women had symptoms (frequency; dysuria; loin pain; smelly urine) or signs (fever; loin tenderness) compatible with urinary tract infection. However there was no significant association between symptoms or signs of infection and bacteriuria or HIV status. A typical range of pathogens, predominantly Enterobacteriaceae, were isolated and there were high rates of resistance to commonly used antimicrobials as well as 10% resistance to ciprofloxacin.Although high rates of significant bacteriuria can occur in highly sexually-active women, this appears unrelated to HIV infection or the level of HIV-related immunosuppression and is generally asymptomatic or clinically indistinct.

Url:

https://api.istex.fr/document/290FA3DB06CDF3914ED0E57BD2DFECB144815DF8/fulltext/pdf

DOI: 10.1016/S0163-4453(96)92719-X

Affiliations:

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Le document en format XML

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<term>Antimicrobial activity</term>
<term>Antimicrobial susceptibilities</term>
<term>Asymptomatic</term>
<term>Asymptomatic bacteriuria</term>
<term>Bacteriuria</term>
<term>Cell counts</term>
<term>Clinical manifestations</term>
<term>Clinical signs</term>
<term>Colony counts</term>
<term>Community clinic</term>
<term>Escherichia coli</term>
<term>Exact test</term>
<term>High rates</term>
<term>Higher rates</term>
<term>Immunocompetent women</term>
<term>Immunosuppression</term>
<term>Infection</term>
<term>Kenyan women</term>
<term>Lancet</term>
<term>Loin pain</term>
<term>Loin tenderness</term>
<term>Mycobacterial culture</term>
<term>Present study</term>
<term>Pyuria</term>
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<term>Seropositive</term>
<term>Sexual activity</term>
<term>Sexual intercourse</term>
<term>Significant association</term>
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<term>Study period</term>
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<term>Urinary</term>
<term>Urinary infection</term>
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<term>Urinary tract infection</term>
<term>Urinary tract infections</term>
<term>Urine</term>
<term>Urine culture</term>
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<front><div type="abstract" xml:lang="en">Although significant bacteriuria and urinary tract infection are more common in immunocompetent women than men, studies linking HIV immunosuppression with an increased risk of developing urinary infection have so far only been carried out in men. We therefore examined the relationship between bacteriuria and HIV status and CD4+cell count in a relatively homogenous cohort of female commercial sex workers (CSW) attending a community clinic in Nairobi. Two hundred and twenty-two women were enroled, and grouped according to HIV status and CD4 count. Group 1 were HIV seronegative (n = 52); Group 2 were HIV seropositive with CD4 + counts above 500 × 106/1 (n = 51); Group 3 were HIV seropositive with CD4 + counts between 201 and 500 × 106/1 (n = 67); Group 4 were HIV seropositive with CD4 + counts below 200 × 106/1 (n = 52). Clinical signs and symptoms were noted and mid-stream specimens of urine obtained for culture and sensitivity.Overall 23% (50/222) had significant bacteriuria. The rates in each group respectively were 25%, 29%, 19% and 23% and there was no significant association between bacteriuria and HIV status; or between bacteriuria and level of immunosuppression as indicated by CD4 + count. Overall 19% (30/222) of women had symptoms (frequency; dysuria; loin pain; smelly urine) or signs (fever; loin tenderness) compatible with urinary tract infection. However there was no significant association between symptoms or signs of infection and bacteriuria or HIV status. A typical range of pathogens, predominantly Enterobacteriaceae, were isolated and there were high rates of resistance to commonly used antimicrobials as well as 10% resistance to ciprofloxacin.Although high rates of significant bacteriuria can occur in highly sexually-active women, this appears unrelated to HIV infection or the level of HIV-related immunosuppression and is generally asymptomatic or clinically indistinct.</div>
</front>
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Bacteriuria in a cohort of predominantly HIV-1 seropositive female commercial sex workers in Nairobi, Kenya

Bacteriuria in a cohort of predominantly HIV-1 seropositive female commercial sex workers in Nairobi, Kenya

Source :

English descriptors

Abstract

Links toward previous steps (curation, corpus...)

Le document en format XML

Pour manipuler ce document sous Unix (Dilib)

Pour mettre un lien sur cette page dans le réseau Wicri